Journal
JOURNAL OF DRUG TARGETING
Volume 18, Issue 4, Pages 277-281Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/10611860903434050
Keywords
Aptamer; daunorubicin; T-cell acute lymphoblastic leukemia; targeted delivery; toxic effect; chemotherapy; PTK7; cell-SELEX
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Funding
- Mashhad University of Medical Sciences
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Application of daunorubicin in treatment of leukemia has been limited for its side effects like cardiotoxicity. Specific delivery of chemotherapy drugs is an important factor in decreasing their side effects. In this study, sgc8, an aptamer for protein tyrosine kinase-7 (PTK7), was used for specific delivery of daunorubicin to Molt-4 cells (PTK7
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