Journal
JOURNAL OF DRUG TARGETING
Volume 18, Issue 6, Pages 420-429Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/10611860903434001
Keywords
Rat; multifunctional liposome; PEG; TAT; SCI; BSCB
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Funding
- National Natural Science Foundation of China [30872603]
- Ministry of Education of China [NCET-06-0251]
- Science and Technology Commission Foundation of Tianjin, China [07JCYBJC10200]
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The blood-spinal cord barrier (BSCB) prevents many macromolecular agents from passing through to reach sites of injury in the spinal cord. This study evaluated the ability of a novel multifunctional liposome modified with polyethylene glycol (PEG) and transactivating-transduction protein (TAT) containing an iron core to cross the BSCB using a rat model of spinal cord injury. Rats were examined daily for a period of three days after spinal cord injury and injection of either the multifunctional modified liposome or control formulations using a 3.0 T magnetic resonance imaging spectrometer. A low signal was observed in the T2-weighted images. Prussian blue staining and flame atomic absorption spectrophotometry revealed that significantly more iron accumulated around the lesion site in the experimental group than the control groups (P<0.05). The findings from this study suggest that this multifunctional liposome carrier can cross the BSCB to accumulate around the lesion site.
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