Journal
JOURNAL OF DRUG TARGETING
Volume 16, Issue 10, Pages 733-740Publisher
INFORMA HEALTHCARE
DOI: 10.1080/10611860802473402
Keywords
Celecoxib; nanoemulsion; bioavailability; skin permeation mechanism
Categories
Funding
- University Grants Commission (UGC), New Delhi, India
Ask authors/readers for more resources
The aim of the present study was to assess the skin permeation mechanism and bioavailability of celecoxib (CXB) using novel nanoemulsion formulation. Fourier transform infrared spectra and differential scanning calorimetric thermogram of skin treated with nanoemulsion indicated that permeation occurred due to the extraction of stratum corneum (SC) lipids by nanoemulsion. The significant decrease in activation energy for CXB permeation across rat skin indicated that the SC lipid bilayers were significantly disrupted (p0.05). Photomicrograph of skin sample showed the disruption and extraction of lipid bilayers as distinct voids and empty spaces visible in the epidermal region. The absorption of CXB through transdermally applied nanoemulsion and nanoemulsion gel resulted in 3.03- and 2.65-fold increases in bioavailability when compared with conventional oral capsule formulation. Overall, these findings indicated that nanoemulsions can be successfully used for the enhancement of skin permeation and bioavailability of poorly soluble drugs.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available