Formulation and optimization of tenoxicam orodispersible tablets by solid deposition technique

Tenoxicam is a poorly water-soluble NSAID drug and dissolution plays an important role in its absorption, so the present investigation was to develop and characterize orodispersible tablets of tenoxicam using solid deposition technique on superdisintegrants in order to improve its dissolution and aqueous solubility to facilitate faster onset of action. The super-disintegrants used were crospovidone, cross-carmellose sodium, sodium starch glycolate and pregelatinised maize starch in ratios of 1:1, 1:2 and 1:4 (w/w) drug:carrier. Drug excipients compatibility study was carried out using DSC, IR spectroscopy and SEM photography. General characterization of the prepared tablets was performed, in addition to wetting time, in vitro disintegration time and in vitro dissolution studies. The formula containing cross-carmellose sodium as a carrier in a ratio of 1:2 showed highest dissolution rate and shortest disintegration time. It was subjected to stability stress testing and drug concentration was detected by stability indicating HPLC assay method and in conclusion, the results of this work suggest that stable rapid release tenoxicam orodispersible tablets can be developed by solid deposition method.