Journal
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
Volume 21, Issue 3, Pages 249-255Publisher
ELSEVIER
DOI: 10.1016/S1773-2247(11)50034-6
Keywords
Hydrogels; pH-sensitive co-polymer; Monomeric composition
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Hydrogels are water-swollen, cross-linked polymeric structures. The objective of this study was to synthesize a new pH-sensitive copolymer, which shows no water uptake at lower pH values but a maximum water uptake at higher pH values. Methyl methacrylate-co-itaconic acid [P(MMAI IA)] hydrogels cross-linked with methylene bis-acrylamide were synthesized. To determine the effect of monomeric composition, copolymers were prepared with different proportions of methyl methacrylale and itaconic acid i.e. 100:0, 90:10, 85:15, 80:20 and 75:25 keeping the degree of cross-linking constant i.e. 0.30 mol %. It was concluded from this study that the MMA/IA 75:25 (x = 0.3 mol %) polymer fulfilled our objective. It seems suitable for delivering the drug above pH 6.
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