Journal
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
Volume 21, Issue 6, Pages 497-501Publisher
ELSEVIER
DOI: 10.1016/S1773-2247(11)50080-2
Keywords
Microemulsions; Thermoreversible polymers; Griseofulvin; Skin uptake
Categories
Ask authors/readers for more resources
Thermoreversible gels formed in situ by oil-in-water microemulsion were evaluated to improve topical deliver), of griseofulvin (GF), a fungistatic antibiotic chosen as a sparingly soluble model drug. Thermogelling microemulsions containing an aqueous solution of temperature-sensitive polymers (methyl cellulose or Poloxamer) as external phase, isopropyl myristate, as oil phase, Tween 20 (PEG(20)sorbitan monolaurate) or Labrasol (PEG-8 caprylic/capric glycerides) or a blend of Epikuron 200 (soybean lecithin) and Oramix NS 10 (decyl polyglucoside), as surfactant, and propylene glycol or L-alanine buthyl ester hydrochloride, as cosolvent/cosurfactant, were prepared. The formulations were characterized by sol-gel transition temperature, viscosity and stability determinations. Stable microemulsions, which showed sol-gel transition near to body temperature, were used as vehicles for GF release experiments at 35 degrees C using full-thickness pig ear skin. Thermogelling microemulsions and control thermogelling solutions showed very low transdermal GF permeation, while the drug accumulation into the skin, after a single 24 h application, was nearly two-fold higher from the microemulsions than from the corresponding polymer solutions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available