Journal
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
Volume 20, Issue 5, Pages 343-347Publisher
ELSEVIER
DOI: 10.1016/S1773-2247(10)50057-1
Keywords
Cisplatin; Ion pairs; SLN; Coacervation
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Funding
- Italian government (MIUR Cofin)
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Coacervation technique a solvent free feasible and versatile method based on a phase transformation from soap micellar solution into fatty acid solid particles by acid addition was used to prepare cisplatin loaded solid lipid nanoparticles (SLN) of stearic acid Different polymers were tested to stabilise SLN suspensions Solubilisation of cisplatin a hydrophilic antitumor agent within sodium stearatic micelles was possible by the formation of a hydrophobic ion pair with sodium dioctylsulfosuccinate Several SLN were produced whose particle size were in the 275 525 nm range. Cisplatin encapsulation efficiency up to 90 % was obtained depending on both stearic acid concentration and stabilisers type and concentration The in vitro cisplatin release showed a burst effect of about 10 20 % corresponding to the non encapsulated drug and then a complete drug release was reached after 24 h
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