Journal
NUCLEIC ACIDS RESEARCH
Volume 44, Issue D1, Pages D356-D364Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkv1178
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Funding
- European Research Council [639125]
- Lundbeck Foundation [R163-2013-16327]
- Danish Council for Independent Research [1331-00180]
- Polish National Science Centre [DEC-2014/12/T/NZ2/00529]
- Lundbeck Foundation [R163-2013-16327] Funding Source: researchfish
- European Research Council (ERC) [639125] Funding Source: European Research Council (ERC)
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Recent developments in G protein-coupled receptor (GPCR) structural biology and pharmacology have greatly enhanced our knowledge of receptor structure-function relations, and have helped improve the scientific foundation for drug design studies. The GPCR database, GPCRdb, serves a dual role in disseminating and enabling new scientific developments by providing reference data, analysis tools and interactive diagrams. This paper highlights new features in the fifth major GPCRdb release: (i) GPCR crystal structure browsing, superposition and display of ligand interactions; (ii) direct deposition by users of point mutations and their effects on ligand binding; (iii) refined snake and helix box residue diagram looks; and (iii) phylogenetic trees with receptor classification colour schemes. Under the hood, the entire GPCRdb front-and back-ends have been recoded within one infrastructure, ensuring a smooth browsing experience and development. GPCRdb is available at http://www.gpcrdb.org/ and it's open source code at https://bitbucket.org/gpcr/protwis.
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