4.8 Article

PCOSKB: A KnowledgeBase on genes, diseases, ontology terms and biochemical pathways associated with PolyCystic Ovary Syndrome

Journal

NUCLEIC ACIDS RESEARCH
Volume 44, Issue D1, Pages D1032-D1035

Publisher

OXFORD UNIV PRESS
DOI: 10.1093/nar/gkv1146

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Funding

  1. Indian Council of Medical Research [RA/285/08-2015, 63/128/2001-BMS]

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Polycystic ovary syndrome (PCOS) is one of the major causes of female subfertility worldwide and approximate to 7-10% of women in reproductive age are affected by it. The affected individuals exhibit varying types and levels of comorbid conditions, along with the classical PCOS symptoms. Extensive studies on PCOS across diverse ethnic populations have resulted in a plethora of information on dysregulated genes, gene polymorphisms and diseases linked to PCOS. However, efforts have not been taken to collate and link these data. Our group, for the first time, has compiled PCOS-related information available through scientific literature; cross-linked it with molecular, biochemical and clinical databases and presented it as a user-friendly, web-based online knowledgebase for the benefit of the scientific and clinical community. Manually curated information on associated genes, single nucleotide polymorphisms, diseases, gene ontology terms and pathways along with supporting reference literature has been collated and included in PCOSKB (http://pcoskb.bicnirrh.res.in).

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