Journal
JOURNAL OF DIGESTIVE DISEASES
Volume 12, Issue 4, Pages 245-256Publisher
WILEY
DOI: 10.1111/j.1751-2980.2011.00511.x
Keywords
drug-induced hepatitis; liver transplantation; primary sclerosing cholangitis; restorative proctocolectomy; ulcerative colitis
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One of typical examples of liver-gut cross talk is the interaction and impact of inflammatory bowel disease (IBD) and hepatobiliary (HB) abnormalities on each other's disease course. There are several layers of association between IBD and HB diseases: (i) HB diseases and IBD share pathogenetic mechanisms; (ii) HB diseases parallel structural and pathophysiological changes seen with IBD; and (iii) hepatic toxicity is associated with medical therapy for IBD. Interdisciplinary approach, involving gastroenterologists, hepatologists and, in advanced cases, general, colorectal, and liver transplant surgeons, is advocated.
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