Journal
JOURNAL OF DIGESTIVE DISEASES
Volume 9, Issue 3, Pages 144-148Publisher
WILEY
DOI: 10.1111/j.1751-2980.2008.00336.x
Keywords
granulocyte chemotactic protein-2; growth-related oncogene-alpha; IBD; interleukin-8; neutrophil chemokine
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OBJECTIVE: To measure the serum levels of neutrophils chemokine granulocyte chemotactic protein-2 (GCP-2) and interleukin-8 (IL-8) in Crohn's disease (CD) and ulcerative colitis (UC) patients and compare them with serum levels of growth-related oncogene (GRO-alpha). METHODS: Forty-two patients with inflammatory bowel disease (24 CD and 18 UC) and 38 matched healthy subjects were recruited. Their serum GCP-2, IL-8 and GRO-alpha were measured by a specific enzyme immunoassay kit. RESULTS: The serum levels of GCP-2 were significantly higher in the CD than the UC patients but lower than in the healthy subjects. The GCP-2 in the UC patients were significantly lower than in the healthy subjects. The GRO-alpha levels were significantly higher in the IBD patients than in the healthy subjects. The IL-8 levels were under the detectable limit in both the IBD and the healthy subjects. CONCLUSION: In this group of patients, GCP-2 did not participate in the inflammatory response in IBD. GRO-alpha could be an important factor that enhances the inflammatory state in IBD.
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