Journal
NUCLEIC ACIDS RESEARCH
Volume 44, Issue D1, Pages D396-D403Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkv1126
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Funding
- National Institutes of Health [R01GM079429]
- EMBL-European Bioinformatics Institute
- UK Medical Research Council [MR/L007835]
- European Commission Framework 7 Programme [284209]
- Wellcome Trust [088944, 104948]
- EMBL-EBI
- National Institutes of Health (NIH) [R01GM079429]
- BBSRC [BB/G022577/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/G022577/1] Funding Source: researchfish
- Medical Research Council [MR/L007835/1] Funding Source: researchfish
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Three-dimensional Electron Microscopy (3DEM) has become a key experimental method in structural biology for a broad spectrum of biological specimens from molecules to cells. The EMDataBank project provides a unified portal for deposition, retrieval and analysis of 3DEM density maps, atomic models and associated metadata (emdatabank.org). We provide here an overview of the rapidly growing 3DEM structural data archives, which include maps in EM Data Bank and map-derived models in the Protein Data Bank. In addition, we describe progress and approaches toward development of validation protocols and methods, working with the scientific community, in order to create a validation pipeline for 3DEM data.
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