Journal
NUCLEIC ACIDS RESEARCH
Volume 43, Issue 4, Pages 2353-2366Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkv070
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Funding
- Biotechnology and Biological Sciences Research Council (BBSRC), UK [BB/E025293/1]
- Wellcome Trust [083130/Z/07/Z]
- Royal College of Surgeons of England [RS123]
- Wellcome Trust Clinical Training Fellowship
- Royal College of Surgeons of England Research Fellowship
- Biotechnology and Biological Sciences Research Council UK
- Engineering and Physical Sciences Research Council UK
- BBSRC
- Wellcome Trust
- Biotechnology and Biological Sciences Research Council [BB/D011795/1, BB/J015067/1, BB/E025293/1] Funding Source: researchfish
- BBSRC [BB/J015067/1, BB/E025293/1, BB/D011795/1] Funding Source: UKRI
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Cancer testis antigens (CTAs) represented a poorly characterized group of proteins whose expression is normally restricted to testis but are frequently up-regulated in cancer cells. Here we show that one CTA, Luzp4, is an mRNA export adaptor. It associates with the TREX mRNA export complex subunit Uap56 and harbours a Uap56 binding motif, conserved in other mRNA export adaptors. Luzp4 binds the principal mRNA export receptor Nxf1, enhances its RNA binding activity and complements Alyref knockdown in vivo. Whilst Luzp4 is up-regulated in a range of tumours, it appears preferentially expressed in melanoma cells where it is required for growth.
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