Journal
NUCLEIC ACIDS RESEARCH
Volume 43, Issue W1, Pages W85-W90Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkv491
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Funding
- National Natural Science Foundation of China [31470068, 81101641, 31200991]
- Sichuan Youth Science and Technology Foundation of China [2014JQ0051]
- Specialized Research Fund for the Doctoral Program of Higher Education [20110032120072]
- Fundamental Research Funds for the Central Universities of China [ZYGX2013J101]
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In 2003, we developed an ab initio program, ZCURVE 1.0, to find genes in bacterial and archaeal genomes. In this work, we present the updated version (i.e. ZCURVE 3.0). Using 422 prokaryotic genomes, the average accuracy was 93.7% with the updated version, compared with 88.7% with the original version. Such results also demonstrate that ZCURVE 3.0 is comparable with Glimmer 3.02 and may provide complementary predictions to it. In fact, the joint application of the two programs generated better results by correctly finding more annotated genes while also containing fewer false-positive predictions. As the exclusive function, ZCURVE 3.0 contains one post-processing program that can identify essential genes with high accuracy (generally >90%). We hope ZCURVE 3.0 will receive wide use with the web-based running mode. The updated ZCURVE can be freely accessed from http://cefg.uestc.edu.cn/zcurve/ or http://tubic.tju.edu.cn/zcurveb/ without any restrictions.
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