Journal
JOURNAL OF DERMATOLOGICAL TREATMENT
Volume 23, Issue 1, Pages 11-15Publisher
INFORMA HEALTHCARE
DOI: 10.3109/09546634.2010.512952
Keywords
clobetasol propionate; clobetasol spray; skin penetration; vehicle metamorphosis
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Clobetasol 0.05% spray, a topical clobetasol propionate, is a non-greasy formulation that has shown increased clinical efficacy in a head-to-head comparison with foam formulation. Moreover, available data from randomized, controlled, doubleblind trials suggests that clobetasol spray is, in fact, slightly more effective than most, if not all, other preparations of clobetasol. The fact that clobetasol spray is exceptionally easy to comply with may have played a major role in this outcome; however, other factors must be considered. These include vehicle metamorphosis post-application as well as vehicle and excipient effects on stratum corneum permeability. Basic concepts in topical drug delivery and how they apply to this spray vehicle may further explain the greater efficacy of clobetasol spray.
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