Journal
JOURNAL OF DERMATOLOGICAL TREATMENT
Volume 20, Issue 1, Pages 55-58Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/09546630802155065
Keywords
DCP; dexamethasone cyclophosphamide pulse therapy; prolonged remission; SLE; systemic lupus erythematosus
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Objective: To put systemic lupus erythematosus (SLE) in remission for a prolonged period. Methods: Dexamethasone cyclophosphamide pulse (DCP) therapy was used in a 40-year-old female with SLE of 3years' duration. DCP therapy comprises an intravenous infusion of 100mg dexamethasone in 500ml of 5% glucose over 1-1 hours on 3 consecutive days along with cyclophosphamide 500mg in the same drip on the first day. This was repeated at 4-week intervals till 9 months after all the lesions cleared. In between the DCP therapy she was given 50mg cyclophosphamide orally daily. Results: The skin lesions cleared with 11 DCP therapies. There was no relapse 24 months after stopping all treatment. Conclusion: DCP therapy appears to put SLE into prolonged remission.
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