Journal
JOURNAL OF DERMATOLOGICAL TREATMENT
Volume 21, Issue 5, Pages 317-318Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/09546630903271563
Keywords
aphthous stomatitis; genital ulceration; nicotine; smoking
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Complex aphthosis, the occurrence of recurrent oral and genital aphthous ulceration without manifestations of systemic disease, is relatively uncommon and of unknown aetiology. We describe a case of complex aphthosis which began within weeks of stopping smoking. After failing to respond to conventional agents, the patient was successfully treated with nicotine lozenges. Recurrent aphthous stomatitis (RAS) is known to be less common in smokers and there have been previous reports of nicotine being used as successful treatments for RAS and Behcet's disease. We discuss the mechanisms of action of nicotine whereby nicotine could influence the natural history of aphthous ulceration. We recommend considering its use when conventional management has failed, particularly in ex-smokers.
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