Journal
JOURNAL OF DENTAL RESEARCH
Volume 91, Issue 12, Pages 1110-1118Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/0022034512462578
Keywords
saliva; enamel; salivary proteins; proteomics; mass spectrometry; microscopy
Categories
Funding
- Natural Sciences and Engineering Research Council of Canada (NSERC) [371813]
- Canadian Institutes of Health Research (CIHR) [106657, 97577, 113166]
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The acquired enamel pellicle (AEP) is a thin acellular film that forms on tooth surfaces upon exposure to the oral environment. It consists predominantly of salivary proteins, but also includes non-salivary-derived proteins, carbohydrates, and lipids. Since it is the interface between teeth and the oral environment, the AEP plays a key role in the maintenance of oral health by regulating processes including lubrication, demineralization, and remineralization and shaping the composition of early microbial flora adhering to tooth surfaces. Knowledge of the 3D structure of the AEP and how that correlates with its protective functions may provide insight into several oral pathological states, including caries, erosion, and periodontal disease. This review intends to update readers about the latest discoveries related to the formation, ultrastructure, composition, and functions of the AEP, as well as the future of pellicle research, with particular emphasis on the emerging role of proteomic and microscopy techniques in oral diagnosis and therapeutics.
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