Journal
JOURNAL OF DENTAL RESEARCH
Volume 91, Issue 8, Pages 745-752Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/0022034512453324
Keywords
temporomandibular disorders; cartilage; gender differences; joint disease; oral and maxillofacial surgery; tissue engineering
Categories
Funding
- National Science Foundation [0812348]
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The debate continues surrounding the use of disc removal (discectomy) as the primary surgical treatment for patients suffering from severe temporomandibular joint disorders. Furthermore, the effectiveness of pre-clinical animal models for predicting the response of the joint to discectomy in humans remains uncertain. This review compares the results of animal models with the most recent clinical findings while also focusing on investigations that use imaging as an assessment tool. After a review of the literature from well-established animal studies to clinical findings, it was found that the results of animal models for discectomy corresponded to the clinical findings seen in patients. Overall, there is adaptive remodeling or degeneration of the TMJ following discectomy. Additionally, there is some reduction in pain but with various amounts of dysfunction remaining following disc removal. Noteworthy, in the most recent clinical studies, imaging was not used as an outcome to assess the success of discectomy at preventing further joint degeneration.
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