Journal
JOURNAL OF DENTAL RESEARCH
Volume 92, Issue 3, Pages 229-234Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/0022034512470830
Keywords
floor of the mouth; neural-crest-derived cells; epithelial-mesenchymal interaction; Fgf7; Dicer; Wnt1Cre
Categories
Funding
- Medical Research Council [MR/J006742/1, G0901599] Funding Source: Medline
- MRC [G0901599] Funding Source: UKRI
- Medical Research Council [G0901599, MR/J006742/1] Funding Source: researchfish
- Grants-in-Aid for Scientific Research [23792215] Funding Source: KAKEN
Ask authors/readers for more resources
The oral mucosa plays critical roles in protection, sensation, and secretion and can be classified into masticatory, lining, and specialized mucosa that are known to be functionally, histologically, and clinically distinct. Each type of oral mucosa is believed to develop through discrete molecular mechanisms, which remain unclear. MicroRNAs (miRNAs) are 19 to 25nt non-coding small single-stranded RNAs that negatively regulate gene expression by binding target mRNAs. miRNAs are crucial for fine-tuning of molecular mechanisms. To investigate the role of miRNAs in oral mucosa development, we examined mice with mesenchymal (Wnt1Cre; Dicer(fl/fl)) conditional deletion of Dicer. Wnt1Cre; Dicer(fl/fl) mice showed trans-differentiation of lining mucosa into an epithelium with masticatory mucosa/skin-specific characteristics. Up-regulation of Fgf signaling was found in mutant lining mucosal epithelium that was accompanied by an increase in Fgf7 expression in mutant mesenchyme. Mesenchyme miRNAs thus have an indirect effect on lining mucosal epithelial cell growth/differentiation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available