Journal
JOURNAL OF DENTAL RESEARCH
Volume 90, Issue 6, Pages 735-739Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/0022034510397614
Keywords
caries; genetics; genetic epidemiology; susceptibility; inheritance
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Funding
- Brazilian Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- INSERM-CNPq [490844/2008-1, ASCIN/CNPq 61/2008]
- CAPES/PDEE
- CAPES/PROSUP
- US Public Health Service, National Center for Research Resources [RR03655]
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Despite recent advances revealing genetic factors influencing caries susceptibility, questions regarding the model of inheritance involved are yet to be addressed. We conducted a Complex Segregation Analysis on decayed teeth in a sample of homogenous, isolated families recruited from the Brazilian Amazon. A dominant, major gene effect controlling resistance to phenotype was detected. The frequency of the resistance allele A was 0.63; mean numbers of decayed teeth were 1.53 and 9.53 for genotypes AA/AB and BB, respectively. These results represent a step toward a description of the exact nature of the genetic risk factors controlling human susceptibility to caries.
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