Journal
JOURNAL OF DENTAL RESEARCH
Volume 89, Issue 11, Pages 1198-1202Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/0022034510381502
Keywords
dental caries; taste preference; genetic association; taste pathway genes
Categories
Funding
- National Institute of Dental and Craniofacial Research [R01-DE014899]
Ask authors/readers for more resources
Dental caries is influenced by a complex interplay of genetic and environmental factors, including dietary habits. Previous reports have characterized the influence of genetic variation on taste preferences and dietary habits. We therefore hypothesized that genetic variation in taste pathway genes (TAS2R38, TAS1R2, GNAT3) may be associated with dental caries risk and/or protection. Families were recruited by the Center for Oral Health Research in Appalachia (COHRA) for collection of biological samples, demographic data, and clinical assessment of oral health, including caries scores. Multiple single-nucleotide polymorphism (SNP) assays for each gene were performed and analyzed by transmission disequilibrium test (TDT) analysis (FBAT software) for three dentition groups: primary, mixed, and permanent. Statistically significant associations were seen in TAS2R38 and TAS1R2 for caries risk and/or protection.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available