Journal
JOURNAL OF DENTAL RESEARCH
Volume 89, Issue 9, Pages 915-920Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/0022034510374056
Keywords
animal model; dental implant; dexamethasone; inferior alveolar nerve; neuropathic pain
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Funding
- Ministry for Health, Welfare and Family Affairs, Republic of Korea [A080028]
- Korea Health Promotion Institute [A080028] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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The analgesic effects of dexamethasone on neuropathic pain have been controversial. The present study investigated the effects of dexamethasone on mechanical allodynia in rats with mal-positioned dental implants. Under anesthesia, the left mandibular second molar was extracted and replaced by a miniature dental implant to injure the inferior alveolar nerve. Nociceptive behavior was examined on each designated day after surgery. Mal-positioned dental implants significantly decreased air-puff thresholds both ipsilateral and contralateral to the injury site. Distinct mechanical hyperalgesia and cold and thermal hypersensitivity were also observed bilaterally. Daily administration of dexamethasone produced prolonged anti-allodynic effects (25 or 50 mg/kg, i.p.), but failed to reduce mechanical allodynia when it had already been established. Therefore, our findings provide that early treatment with dexamethasone is important in the treatment of nociceptive behavior suggestive of trigeminal neuropathic pain.
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