Journal
JOURNAL OF DENTAL RESEARCH
Volume 90, Issue 1, Pages 9-17Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/0022034510378683
Keywords
epigenetics; histone modifications; DNA methylation; inflammation
Categories
Funding
- NIDCR [DE18412, DE017205]
- Connecticut Stem Cell grant [09-SCB-UCHC]
- NATIONAL INSTITUTE OF DENTAL &CRANIOFACIAL RESEARCH [R01DE017205, K02DE018412] Funding Source: NIH RePORTER
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Epigenetic modifications occur in response to environmental changes and play a fundamental role in gene expression following environmental stimuli. Major epigenetic events include methylation and acetylation of histones and regulatory factors, DNA methylation, and small non-coding RNAs. Diet, pollution, infections, and other environmental factors have profound effects on epigenetic modifications and trigger susceptibility to diseases. Despite a growing body of literature addressing the role of the environment on gene expression, very little is known about the epigenetic pathways involved in the modulation of inflammatory and anti-inflammatory genes. This review summarizes the current knowledge about epigenetic control mechanisms during the inflammatory response.
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