Journal
JOURNAL OF DENTAL RESEARCH
Volume 88, Issue 7, Pages 621-626Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/0022034509339291
Keywords
periodontal; ligament; disease; polymorphisms; integrins
Categories
Funding
- The Research Council of Norway
- Meltzer Foundation
- University of Bergen
- Helse Vest
Ask authors/readers for more resources
We previously demonstrated a role for alpha 11 beta 1 integrin in periodontal ligament (PDL)-driven tooth eruption in the mouse. To explore a possible role for alpha 11 beta 1 in the human periodontium, we have characterized the expression and function of alpha 11 in human PDL tissue, in human PDL fibroblasts (hPDLF), and in human gingival fibroblasts (hGF). alpha 11 expression was detected in PDL tissue, in hPDLF, and in hGF cells. Platelet-derived growth factor-BB and insulin-like growth factor II stimulated contraction of collagen lattices by both types of fibroblasts. alpha 2 integrin blocking antibodies and the use of alpha 11 siRNA demonstrated a role for both alpha 2 beta 1 and alpha 11 beta 1 in collagen lattice remodeling. Analysis of the proximal ITGA11 promoter from persons with chronic periodontal disease failed to reveal any polymorphism. Analysis of our data shows that alpha 11 beta 1 is a major collagen receptor on cultured human PDL cells and implies that it is also functionally important in the PDL in vivo.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available