Journal
JOURNAL OF DENTAL RESEARCH
Volume 88, Issue 10, Pages 894-903Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/0022034509343143
Keywords
radiation; salivary gland dysfunction; salivary glands; animal models; therapy; xerostomia
Categories
Funding
- NIH [K22 DE16096, R03 DE017918, R01 DE18888]
- University of Arizona
- NSF GK-12 Graduate Student Fellowship [NSF 0338247]
- University of Arizona CATTS program
- Cancer Biology Training [T32 CA09213-30]
- NATIONAL CANCER INSTITUTE [T32CA009213, P30CA023074] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH [R01DE018888] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DENTAL &CRANIOFACIAL RESEARCH [K22DE016096, R03DE017918] Funding Source: NIH RePORTER
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Radiation therapy for head and neck cancer causes significant secondary side-effects in normal salivary glands, resulting in diminished quality of life for these individuals. Salivary glands are exquisitely sensitive to radiation and display acute and chronic responses to radiotherapy. This review will discuss clinical implications of radiosensitivity in normal salivary glands, compare animal models used to investigate radiation-induced salivary gland damage, address therapeutic advances, and project future directions in the field.
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