Journal
JOURNAL OF DAIRY SCIENCE
Volume 91, Issue 10, Pages 3768-3778Publisher
AMER DAIRY SCIENCE ASSOC
DOI: 10.3168/jds.2008-1305
Keywords
oligosaccharide; bovine milk; high-performance liquid chromatography; mass spectrometry
Funding
- California Dairy Research Foundation
- Dairy Management Inc. (Rosemont, IL)
- University of California Discovery
- National Institutes of Health (Bethesda, MD)
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Bovine milk oligosaccharides have several potentially important biological activities including the prevention of pathogen binding to the intestinal epithelial and as nutrients for beneficial bacteria. It has been suggested that milk oligosaccharides are an important source of complex carbohydrates as supplements for the food and the pharmaceutical industries. However, only a small number of structures of bovine milk oligosaccharides (bMO) are known. There have been no systematic studies on bMO. High-performance mass spectrometry and separation methods are used to evaluate bMO, and nearly 40 oligosaccharides are present in bovine milk. Bovine milk oligosaccharides are composed of shorter oligomeric chains than are those in human milk. They are significantly more anionic with nearly 70%, measured abundances, being sialylated. Additionally, bMO are built not only on the lactose core (as are nearly all human milk oligosaccharides), but also on lactose amines. Sialic acid residues include both N-acetyl and N-glycolylneuraminic acid, although the former is significantly more abundant.
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