Journal
JOURNAL OF CYSTIC FIBROSIS
Volume 18, Issue 3, Pages 313-320Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jcf.2018.08.009
Keywords
Cystic fibrosis; Bile acids; Metabolism; Intestine; Liver
Categories
Ask authors/readers for more resources
With the improved treatment of the pulmonary complications of cystic fibrosis (CF), gastrointestinal problems have become more important in the morbidity in CF. A hallmark of the gastrointestinal phenotype of CF, apart from pancreatic insufficiency, is a disruption of bile acid homeostasis. Bile acid homeostasis is important for many gastrointestinal processes including fat absorption, inflammation, microbial composition, as well as regulation of whole body energy metabolism. This review describes the impairment of bile acid homeostasis in CF, its possible consequences for gastrointestinal and metabolic complications and its potential as a target for therapy. (C) 2018 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available