Journal
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS
Volume 353, Issue -, Pages 46-55Publisher
ELSEVIER
DOI: 10.1016/j.nimb.2015.04.024
Keywords
Nanodosimetry; Monte Carlo; GATE; Geant4-DNA
Categories
Funding
- Conseil General de l'Allier
- France-Korea Particle Physics and e-science Laboratory (FKPPL) International Associated Laboratory
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The GATE Monte Carlo simulation platform based on the Geant4 toolkit is in constant improvement for dosimetric calculations. In this paper, we present the integration of Geant4-DNA processes into the GATE 7.0 platform in the objective to perform multi-scale simulations (from macroscopic to nanometer scale). We simulated three types of clinical and preclinical beams: a 6 MeV electron clinical beam, a X-ray irradiator beam and a clinical proton beam for which we validated depth dose distributions against measurements in water. Frequencies of energy depositions and DNA damage were evaluated using a specific algorithm in charge of allocating energy depositions to atoms constituting DNA molecules represented by their PDB (Protein Data Bank) description. (C) 2015 Elsevier B.V. All rights reserved.
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