Journal
JOURNAL OF CUTANEOUS PATHOLOGY
Volume 39, Issue 10, Pages 911-917Publisher
WILEY
DOI: 10.1111/j.1600-0560.2012.01964.x
Keywords
cancer; cutaneous neoplasm; immunohistochemistry; non-melanoma skin cancer; p63
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Funding
- NCI [P30 CA082103]
- UC Cancer Research Coordinating Committee
- VA Merit Award
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Merkel cell carcinoma (MCC) represents a cutaneous malignancy with high associated mortality. Numerous studies have attempted to define characteristics to more accurately predict outcome. Two recent studies have demonstrated that Merkel cell polyomavirus (MCPyV) seropositivity correlated with a better prognosis, while a third study revealed no difference. Expression of p63 by tumor cell nuclei has been shown to be associated with a worse prognosis in a European cohort. To better understand the relationship between prognosis and MCPyV or p63 status, we used immunohistochemistry to evaluate both attributes in 36 US patients with MCC. Our results show that when considered as a binary variable, p63 expression represents a strong risk factor (p?
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