Journal
JOURNAL OF CUTANEOUS PATHOLOGY
Volume 36, Issue 5, Pages 553-559Publisher
WILEY
DOI: 10.1111/j.1600-0560.2008.01112.x
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Funding
- British Heart Foundation
- European Commission 5th Framework Program [QLG1-CT-2000-01091]
- March of Dimes
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Desmoplakin plays a vital role in cell adhesion, linking the transmembrane desmosomal complex to the cytoskeletal network. Clues to the biological significance of desmoplakin have emerged from the embryonic lethal phenotype of null mice and from naturally occurring human desmoplakin mutations, which cause cardiocutaneous phenotypes. In this study, we describe a child who presented with the unique constellation of bullous dermatosis, profound plantar keratoderma, alopecia totalis and cardiomyopathy leading to sudden cardiac death at the age of 9 years. This complex cardiocutaneous phenotype is associated with compound heterozygosity for two novel nonsense desmoplakin mutations. Histological examination of a plantar skin biopsy showed full thickness epidermal acantholysis with superimposed spongiosis, hyperorthokeratosis and focal parakeratosis. Immunohistochemistry and quantitative confocal microscopy showed abnormal tissue distribution and reduced levels of expression for plakoglobin, desmoplakin and connexin 43 at epidermal junctional sites. Interpretation of the changes in the context of the two mutations provides insight into the mechanism of clinical cell adhesion disease. Asimaki A, Syrris P, Ward D, Guereta LG, Saffitz JE, McKenna WJ. Unique epidermolytic bullous dermatosis with associated lethal cardiomyopathy related to novel desmoplakin mutations.J Cutan Pathol 2009; 36: 553-559. (C) 2008 Blackwell Munksgaard.
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