Journal
JOURNAL OF CROHNS & COLITIS
Volume 8, Issue 11, Pages 1506-1515Publisher
OXFORD UNIV PRESS
DOI: 10.1016/j.crohns.2014.06.004
Keywords
Inflammatory bowel diseases; Inception cohort; Incidence
Categories
Funding
- Danish Colitis Crohn Patients Organization (CCF)
- Vibeke Binder and Povl Riis' Foundation
- Scientific Council at Herlev Hospital
- Sigrid Rigmor Moran Foundation
- Aage and Johanne Louis-Hansens Foundation
- Munkholm Foundation
- C.C. Klestrup and Henriette Klestrup Foundation
- Knud and Dagny Gad Andresens Foundation
- Else and Mogens Wedell-Wedellsborgs Foundation
- Direktor Jacob Madsen and Olga Madsens Foundation
- Scan Vet
- Torben og Alice Frimodt Foundation
- Laegernes forsikringsforening
- Bengt Ihre's foundation
- Nanna Svartz' foundation
- Orebro University Hospital Research Foundation
- Orebro County Research Foundation
- Swedish Foundation
- Swedish Research Council
- Swedish Society of Medicine
- Research Council of South-East Sweden
- County Council of osterglitland
- Swedish Organization
- International Organization of Inflammatory Bowel Diseases (IOIBD)
- Competitive State Research Financing of the Expert Responsibility Area of Tampere University Hospital [9P008]
- ECCO
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Background and aims: The aim of the present study was to validate the IBD (inflammatory bowel diseases) incidence reported in the 2010 ECCO-EpiCom (European Crohn's and Colitis Organization-Epidemiological Committee) inception cohort by including a second independent inception cohort from participating centers in 2011 and an Australian center to investigate whether there is a difference in the incidence of IBD between Eastern and Western European countries and Australia. Methods: Fourteen centers from 5 Eastern and 9 Western European countries and one center from Australia participated in the ECCO-EpiCom 2011 inception cohort. Patients' data regarding disease type, socio-demographic factors, extraintestinal manifestations and therapy were entered into the Web-based EpiCom database, www.ecco-epicom.eu. Results: A total of 711 adult patients were diagnosed during the inclusion year 2011, 178 (25%) from Eastern, 461 (65%) from Western Europe and 72 (10%) from Australia; 259 (37%) patients were diagnosed with Crohn's disease, 380 (53%) with ulcerative colitis and 72 (10%) with IBD unclassified. The mean annual incidence rate for IBD was 11.3/100,000 in Eastern Europe, 14.0/100,000 in Western Europe and 30.3/100,000 in Australia. Significantly more patients were diagnosed with complicated disease at diagnosis in Eastern Europe compared to Western Europe (43% vs. 27%, p = 0.02). Conclusion: Incidence rates, disease phenotype and initial treatment characteristics in the 2011 ECCO-EpiCom cohort were not significantly different from that reported in the 2010 cohort. (C) 2014 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved.
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