Journal
JOURNAL OF CROHNS & COLITIS
Volume 8, Issue 9, Pages 1030-1042Publisher
OXFORD UNIV PRESS
DOI: 10.1016/j.crohns.2014.01.028
Keywords
Quality of life; Epidemiology; Inception cohort; Disease course
Categories
Funding
- Danish Colitis Crohn Patients Organization (CCF)
- Vibeke Binder and Povl Riis Foundation
- Scientific Council at Herlev Hospital
- Sigrid Rigmor Moran Foundation
- Aage and Johanne Louis-Hansens Foundation
- Munkholm Foundation
- C.C. Klestrup and Henriette Klestrup Foundation
- Knud and Dagny Gad Andresens Foundation
- Else and Mogens Wedell-Wedellsborgs Foundation
- Direktor Jacob Madsen and Olga Madsens Foundation
- ScanVet
- Torben og Alice Frimodt Foundation
- Laegernes forsikringsforening af 1891
- Bengt Ihre's foundation, Nanna Svartz' foundation
- Orebro University Hospital Research Foundation
- Orebro County Research Foundation
- Swedish Foundation for Gastrointestinal research
- Swedish Research Council
- Swedish Society of Medicine
- Research Council of South-East Sweden
- County Council of ostergotland
- Swedish Organization for the study of inflammatory bowel disease
- Competitive State Research Financing of the Expert Responsibility Area of Tampere University Hospital
- European Crohn's and Colitis Organization
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Background Et Aims: Health-related quality of life (HRQoL) is impaired in patients with Inflammatory Bowel Disease (IBD). The aim was prospectively to assess and validate the pattern of HRQoL in an unselected, population-based inception cohort of IBD patients from Eastern and Western Europe. Methods: The EpiCom inception cohort consists of 1560 IBD patients from 31 European centres covering a background population of approximately 10.1 million. Patients answered the disease specific Short Inflammatory Bowel Disease Questionnaire (SIBDQ) and generic Short Form 12 (SF-12) questionnaire at diagnosis and after one year of follow-up. Results: In total, 1079 patients were included in this study. Crohn's disease (CD) patients mean SIBDQ scores improved from 45.3 to 55.3 in Eastern Europe and from 44.9 to 53.6 in Western Europe. SIBDQ scores for ulcerative colitis (UC) patients improved from 44.9 to 57.4 and from 48.8 to 55.7, respectively. UC patients needing surgery or biologicals had lower SIBDQ scores before and after compared to the rest, while biological therapy improved SIBDQ scores in CD. CD and UC patients in both regions improved all SF-12 scores. Only Eastern European UC patients achieved SF-12 summary scores equal to or above the normal population. Conclusion: Medical and surgical treatment improved HRQoL during the first year of disease. The majority of IBD patients in both Eastern and Western Europe reported a positive perception of disease-specific but not generic HRQoL. Biological therapy improved HRQoL in CD patients, while UC patients in need of surgery or biological therapy experienced lower perceptions of HRQoL than the rest. (C) 2014 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved.
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