Journal
JOURNAL OF CROHNS & COLITIS
Volume 4, Issue 4, Pages 367-376Publisher
OXFORD UNIV PRESS
DOI: 10.1016/j.crohns.2010.05.011
Keywords
Inflammatory bowel diseases; Crohn's disease; Ulcerative colitis; TNF alpha; Anti-TNF therapy; Paradoxical inflammation
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Funding
- ArdeyPharm
- Travacare
- Fresenius
- UCB Pharma
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This second section of the first ECCO pathogenesis workshop on anti-TNF therapy failures in inflammatory bowel diseases addresses the biological roles of TNF alpha and the effects and mechanisms of action of TNF alpha antagonists. Mechanisms underlying their failure, including induction of TNF-independent inflammatory pathways and phenomena of paradoxical inflammation are discussed. (C) 2010 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved.
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