Journal
JOURNAL OF COORDINATION CHEMISTRY
Volume 67, Issue 16, Pages 2783-2794Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/00958972.2014.938065
Keywords
Ceftriaxone lead(II) complex; DFT; IR spectroscopy; TGA; Antibacterial screening
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Funding
- RFBR [14-03-31, 170 MOJI_a]
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A Pb(II) complex with ceftriaxone (H2Ceftria) antibiotic was synthesized by reaction of ceftriaxone disodium salt (hemi) heptahydrate with lead nitrate in water-ethanol medium. The complex was characterized on the basis of complexometric titration, spectrophotometric and thermogravimetric analyses, capillary electrophoresis, IR, Raman and UV-vis spectroscopies, and density functional theory calculations. Pb(II) is five-coordinate with distorted square pyramidal geometry. The coordination of Ceftria(2-) to Pb(II) occurs through N and O of the triazine, lactam carbonyl, carboxylate, and amine groups. The antibacterial activity study showed that Klebsiella pneumoniae is resistant to [Pb(Ceftria)]center dot 3H(2)O. The antibacterial activity of [Pb(Ceftria)]center dot 3H(2)O against Staphylococcus aureus is reduced compared with ceftriaxone. In contrast, the antibacterial activity of [Pb(Ceftria)]center dot 3H(2)O against Escherichia coli is 28% higher than that of ceftriaxone antibiotic.
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