Journal
JOURNAL OF COORDINATION CHEMISTRY
Volume 67, Issue 13, Pages 2344-2356Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/00958972.2014.938064
Keywords
Copper(II)-based complexes; Crystal structure; Cytotoxicity
Categories
Funding
- National Natural Science Foundation of China [21371046]
- He'nan key science and technology research [112102310084, 122102310061, 132102310121]
- foundation of Training Program for young key teacher of Henan University of Urban Construction
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Three coordination compounds with heterocyclic ligands were constructed to investigate the potential cytotoxicity of copper(II)-based complexes. IC50 values revealed that complexes 2 and 3 show strong cytotoxicity, whereas complex 1 is weakly cytotoxic after being tested by MTT assay against a panel of several human alimentary system carcinoma cell lines. To investigate the potential cytotoxicity of copper(II)-based complexes, three coordination compounds with heterocyclic ligands, Cu(pbmbt)Cl-2(CH3OH) (1), Cu-2(ddbib)(2)(NO3)(4)center dot 3CH(3)OH (2), and Cu-3(ttmtmb)(2)Cl-6 center dot 2.5H(2)O (3), which include mononuclear, dinuclear, and trinuclear structures, have been synthesized from reactions of corresponding copper(II) salts with 1-((2-pyrazinyl)-1H-benzoimidazol-1-yl)methyl)-1H-benzotriazole (pbmbt), 2-(2,3-dihydropyrazin-2-yl)-1-((4-2-((2,3-dihydropyrazin-2-yl)-1H-benzo[d]imidazol-1-yl)methyl)phenyl)methyl)-1H-benzo[d]imidazole (ddbib), and 1,1',1''-((2,4,6-trimethylbenzene-1,3,5-triyl)tris(methylene)tris(2-methyl-1H-benzoimidazole) (ttmtmb), respectively. IC50 values revealed that 2 and 3 show strong cytotoxicity, whereas 1 is weakly cytotoxic after being tested against a panel of several human alimentary system carcinoma cell lines (SGC7901, EC109, SMMC7721, and HT29). The number of copper centers and different structures could make a tremendous difference on their cytotoxicity.
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