Journal
JOURNAL OF COORDINATION CHEMISTRY
Volume 66, Issue 4, Pages 602-611Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/00958972.2013.765950
Keywords
Polyoxometalate; Quinolone; Antitumor activity; Copper; Nickel
Categories
Funding
- National Natural Science Foundation [21271089]
- Scientific and technological innovation team [2012TD010]
- Postdoctoral Foundation in Heilongjiang Province
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Three new quinolone drug molecules modifying Keggin polyoxometalate compounds have been synthesized under hydrothermal conditions and structurally characterized. Single-crystal X-ray diffraction analysis shows that Keggin clusters modified by [Cu2(Enro)3H2O]4+ subunits result in formation of dimer {[Cu2(Enro)3H2O][SiW12O40]}2 in 1; in 2, Keggin clusters are modified by two [Cu(Norf)2]2+ subunits in the symmetrical coordinated mode, and then, discrete [Cu2(Norf)4][SiW12O40] is obtained; in 3, Keggin clusters are fused together via [Ni(Enro)2]2+ subunits giving the 1D drug-polyoxometalates (POMs) hybrid chain. Antitumor activities in vitro show that 3 exhibits good antitumor activity, while 1 and 2 and their parent SiW12 show no anti-SGC7901 or anti-SMMC7721 activities, indicating that the antitumor activities rest on differences of metal ions, differently affecting electron transfer between quinolone and POMs.
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