Journal
JOURNAL OF COORDINATION CHEMISTRY
Volume 64, Issue 17, Pages 2974-2983Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/00958972.2011.610102
Keywords
La(III) complex; PMFP-isonicotinoyl hydrazone; DNA-binding properties; Antioxidant activities
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Funding
- National Natural Science Foundation of China [20975046]
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A Schiff-base ligand derived from 1-phenyl-3-methyl-4-formyl-2-pyrazolin-5-one (PMFP) and isoniazid was prepared and its La(III) complex was characterized by X-ray single crystal diffraction. The La(III) is nine-coordinate in a space group P2(1)/n. DNA-binding was investigated by UV-Vis, fluorescence titration, ethidium bromide displacement experiments, and viscosity measurements, which indicated that the ligand and La(III) complex strongly binds to calf thymus DNA presumably via groove binding and intercalation. The intrinsic binding constants of the ligand and La(III) complex were 0.86 x 10(5) and 2.46 x 10(5) mol L-1, respectively. Antioxidant data from hydroxyl radical scavenging experiments in vitro suggest that the La(III) complex possesses higher scavenging ratio than the free ligand, metallic salt, and some standard antioxidants like mannitol.
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