Journal
JOURNAL OF COORDINATION CHEMISTRY
Volume 62, Issue 4, Pages 613-621Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/00958970802291480
Keywords
Ceftazidime; Metalloantibiotics; Metal complexes
Categories
Funding
- Comision de Investigacion from the Universidad de Oriente
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Ceftazidime (Hceftaz) interacts with transition metal(II) ions to give octahedral [M(ceftaz)(H2O)Cl] complexes [M = Mn(II), Fe(II), Co(II), Ni(II), Cu(II) and Cd(II)] which were characterized by physicochemical and spectroscopic methods. The spectra indicated that the ligand is a multidentate chelating agent. The complexes are insoluble in water and common organic solvents and probably have polymeric structures. The antibacterial activity of the metal complexes was found to be lower than that of free ceftazidime.
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