Journal
JOURNAL OF CONTROLLED RELEASE
Volume 183, Issue -, Pages 77-86Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jconrel.2014.03.026
Keywords
PEG-PLGA copolymers; Structure types; Drug delivery applications; Drug loading; Drug release; Target delivery
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In the paper, we begin by describing polyethylene glycol-poly lactic acid-co-glycolic acid (PEG-PLGA) which was chosen as a typical model copolymer for the construction of nano-sized drug delivery systems and also the types of PEG-PLGA copolymers that were eluted. Following this we examine the structure-influenced drug delivery applications including nanoparticles, micelles and hydrogels. After that, the preparation methods for nano-sized delivery systems are presented. In addition, the drug loading mode of PEG-PLGA micelles is divided into three aspects. Finally, the drug release profiles of PEG-PLGA micelles, both in terms of their in vitro and in vivo characteristics, are represented. PEG-PLGA copolymers are very suitable for the construction of micelles as carriers for insoluble drugs. This article reviews the structure and the different structure-influenced applications of PEG-PLGA copolymers, concentrating on the application of PEG-PLGA micelles. (C) 2014 Elsevier B.V. All rights reserved.
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