Journal
JOURNAL OF CONTROLLED RELEASE
Volume 193, Issue -, Pages 27-34Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jconrel.2014.07.005
Keywords
3-Dimensional fabrication; Degradable polymer; Spatial distribution; Inks; Composites
Funding
- Australian Research Council (ARC) [CE140100012]
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Drug delivery from 3-dimensional (3D) structures is a rapidly growing area of research. It is essential to achieve structures wherein drug stability is ensured, the drug loading capacity is appropriate and the desired controlled release profile can be attained. Attention must also be paid to the development of appropriate fabrication machinery that allows 3D drug delivery systems (DDS) to be produced in a simple, reliable and reproducible manner. The range of fabrication methods currently being used to form 3D DDSs include electrospinning (solution and melt), wet-spinning and printing (3-dimensional). The use of these techniques enables production of DDSs from the macro-scale down to the nano-scale. This article reviews progress in these fabrication techniques to form DDSs that possess desirable drug delivery kinetics for a wide range of applications. (C) 2014 Elsevier B.V. All rights reserved.
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