Journal
JOURNAL OF CONTROLLED RELEASE
Volume 190, Issue -, Pages 82-93Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jconrel.2014.05.004
Keywords
Organ-on-a-chip; Drug delivery; Nanoparticle; Drug screening; Toxicity
Funding
- Office of Naval Research Young National Investigator Award
- National Institutes of Health [HL092836, DE019024, EB012597, AR057837, DE021468, HL099073, EB008392]
- Presidential Early Career Award for Scientists and Engineers (PECASE)
- Portuguese Foundation for Science and Technology (FCT) [SFRH/BD/51679/2011]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/51679/2011] Funding Source: FCT
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Novel microfluidic tools allow new ways to manufacture and test drug delivery systems. Organ-on-a-chip systems - microscale recapitulations of complex organ functions - promise to improve the drug development pipeline. This review highlights the importance of integrating microfluidic networks with 3D tissue engineered models to create organ-on-a-chip platforms, able to meet the demand of creating robust preclinical screening models. Specific examples are cited to demonstrate the use of these systems for studying the performance of drug delivery vectors and thereby reduce the discrepancies between their performance at preclinical and clinical trials. Wealso highlight the future directions that need to be pursued by the research community for these proof-of-concept studies to achieve the goal of accelerating clinical translation of drug delivery nanoparticles. (C) 2014 Elsevier B. V. All rights reserved.
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