Journal
JOURNAL OF CONTROLLED RELEASE
Volume 194, Issue -, Pages 1-19Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jconrel.2014.08.015
Keywords
Stimuli-response; Nanomaterials; Protein/peptide therapeutics; Drug delivery; Nanomedicine
Funding
- American Diabetes Association (ADA)
- NIH's Clinical and Translational Science Awards (CTSA) at UNC-CH [1UL1TR001111]
- NC State Faculty Research and Professional Development Award
- Joint BME Department of UNC-CH and NCSU
- NC TraCS [550KR51307]
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Protein therapeutics have emerged as a significant role in treatment of a broad spectrum of diseases, including cancer, metabolic disorders and autoimmune diseases. The efficacy of protein therapeutics, however, is limited by their instability, immunogenicity and short half-life. In order to overcome these barriers, tremendous efforts have recently been made in developing controlled protein delivery systems. Stimuli-triggered release is an appealing and promising approach for protein delivery and has made protein delivery with both spatiotemporal- and dosage-controlled manners possible. This review surveys recent advances in controlled protein delivery of proteins or peptides using stimuli-responsive nanomaterials. Strategies utilizing both physiological and external stimuli are introduced and discussed. (C) 2014 Elsevier B.V. All rights reserved.
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