Journal
JOURNAL OF CONTROLLED RELEASE
Volume 190, Issue -, Pages 210-218Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jconrel.2014.04.014
Keywords
Gelatin; Drug delivery; Cell delivery; Controlled release; Composite material
Funding
- U.S. Army [W81XWH-14-2-0004]
- U.S. Navy [W81XWH-14-2-0004]
- U.S. NIH [W81XWH-14-2-0004]
- U.S. Air Force [W81XWH-14-2-0004]
- U.S. VA [W81XWH-14-2-0004]
- U.S. Health Affairs [W81XWH-14-2-0004]
- National Institutes of Health [R01 AR048756, R01 AR057083]
- Baylor College of Medicine Medical Scientist Training Program [NIH T32 GM007330]
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The ability of gelatin to form complexes with different drugs has been investigated for controlled release applications. Gelatin parameters, such as crosslinking density and isoelectric point, have been tuned in order to optimize gelatin degradation and drug delivery kinetics. In recent years, focus has shifted away from the use of gelatin in isolation toward the modification of gelatin with functional groups and the fabrication of material composites with embedded gelatin carriers. In this review, we highlight some of the latest work being performed in these areas and comment on trends in the field. Specifically, we discuss gelatin modifications for immune system evasion, drug stabilization, and targeted delivery, as well as gelatin composite systems based on ceramics, naturally-occurring polymers, and synthetic polymers. (C) 2014 Elsevier B.V. All rights reserved.
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