Journal
JOURNAL OF CONTROLLED RELEASE
Volume 169, Issue 3, Pages 180-184Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jconrel.2012.11.012
Keywords
Polymeric micelles; Nanoparticles; pH sensitive; Cancer diagnosis; Targeted therapy
Funding
- National Research Foundation of Korea (NRF)
- Korean Government (MEST) [2010-0027955, 2011-0019391]
- NRF
- National Research Foundation of Korea [2010-0027955, 2011-0019391] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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The delivery and control over the release of hydrophobic imaging markers for cancer diagnosis or pharmaceutical agents for targeted therapy are of considerable interest. Nano-sized pH-sensitive polymeric micelles that rely on the enhanced permeability and retention (EPR) of vasculature and the low-pH microenvironment in cancer tissue are emerging as stimuli-responsive targeted therapies that can simultaneously release diagnostic and therapeutic agents into a cancerous region. This review focuses on the developments of pH-sensitive polymeric micelles and their biomedical applications in cancer diagnosis and targeted therapy. (C) 2012 Elsevier B. V. All rights reserved.
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