Journal
JOURNAL OF CONTROLLED RELEASE
Volume 165, Issue 1, Pages 29-37Publisher
ELSEVIER
DOI: 10.1016/j.jconrel.2012.10.015
Keywords
Modeling; Controlled release drug delivery; PLGA; Autocatalysis; Bulk degradation; Degradable polymer
Funding
- National Institutes of Health [NIBIB 5RO1EB005181]
- National Science Foundation [0426328]
- U.S. Department of Energy Computational Science Graduate Fellowship Program of the Office of Science and National Nuclear Security Administration in the Department of Energy [DE-FG02-97ER25308]
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PLGA microspheres are widely studied for controlled release drug delivery applications, and many models have been proposed to describe PLGA degradation and erosion and drug release from the bulk polymer. Autocatalysis is known to have a complex role in the dynamics of PLGA erosion and drug transport and can lead to size-dependent heterogeneities in otherwise uniformly bulk-eroding polymer microspheres. The aim of this review is to highlight mechanistic, mathematical models for drug release from PLGA microspheres that specifically address interactions between phenomena generally attributed to autocatalytic hydrolysis and mass transfer limitation effects. Predictions of drug release profiles by mechanistic models are useful for understanding mechanisms and designing drug release particles. (C) 2012 Elsevier B.V. All rights reserved.
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