Journal
JOURNAL OF CONTROLLED RELEASE
Volume 171, Issue 2, Pages 152-162Publisher
ELSEVIER
DOI: 10.1016/j.jconrel.2013.06.006
Keywords
Aptamer; Drug delivery; Gene delivery; Nanoparticle; Cancer therapy
Funding
- National Natural Science Funds for Excellent Young Scholar [81222047]
- Ministry of Education Program for New Century Excellent Talents [NCET-11-0454]
Ask authors/readers for more resources
Aptamers are a class of oligonucleotides that can specifically bind to different targets with high affinity. Since their discovery in 1980s, aptamers have attracted considerable interests in medical applications. So far, initial research using aptamers as delivery systems has produced exciting results. In this review, we summarize recent progress in aptamer-mediated chemotherapeutic drug and siRNA delivery systems in tumor treatment. With regard to chemotherapeutic drugs, the 2 main methods for targeted delivery using aptamers are as follows: aptamer-drug systems (in which aptamers directly deliver the drug both as a carrier and as a ligand) and aptamer-nanoparticles systems (in which nanoparticles function together with aptamers for targeted delivery of drugs). For delivery of siRNA, aptamers can be utilized by the following ways to facilitate targeting: (1) linked by a connector; (2) form a chimera; and (3) combined with nanoparticles. In co-delivery system, the advantages associated with the use of aptamers are beginning to become apparent also. Here, the challenges and new perspectives in the field of aptamer-mediated delivery have been discussed. (C) 2013 Published by Elsevier B.V.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available