Journal
JOURNAL OF CONTROLLED RELEASE
Volume 167, Issue 3, Pages 323-332Publisher
ELSEVIER
DOI: 10.1016/j.jconrel.2013.02.021
Keywords
Non-viral gene delivery; Cell-penetrating peptides; TAT-PTD; Nanotechnology; Molecular therapy
Funding
- CSIR-Centre for Cellular and Molecular Biology
- Department of Science and Technology, Govt. of India
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Non-viral gene therapy approaches have strongly established the utility of peptides as integral constituents of delivery platforms devised for efficient transfer of therapeutic molecules into cells. Among these, cell-penetrating peptides (CPPs), encompassing a family of short peptide sequences and their chimeric derivatives, have gained versatility through the addition of de novo peptide ligands primarily to facilitate cell-specific nucleic acid delivery in vitro and in vivo. The review illustrates the structural requirements of a noteworthy peptide TAT-PTD and other derivatives chiefly to exemplify their implication in gene therapy. An overview of the emerging concept and recent explorations will be presented through unique examples which form a facet in nanotechnology-based cancer therapy. Finally the basis for the utility of CPPs in plants will be discussed in view of its biotechnological potential. (C) 2013 Elsevier B. V. All rights reserved.
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