Journal
JOURNAL OF CONTROLLED RELEASE
Volume 159, Issue 1, Pages 2-13Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jconrel.2011.10.023
Keywords
Peptides; Cancer; Nanomedicine; Drug delivery; Tumor targeting; Protease-responsive
Funding
- National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH)
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Peptides are attracting increasing attention as therapeutic agents, as the technologies for peptide development and manufacture continue to mature. Concurrently, with booming research in nanotechnology for biomedical applications, peptides have been studied as an important class of components in nanomedicine, and they have been used either alone or in combination with nanomaterials of every reported composition. Peptides possess many advantages, such as smallness, ease of synthesis and modification, and good biocompatibility. Their functions in cancer nanomedicine, discussed in this review, include serving as drug carriers, as targeting ligands, and as protease-responsive substrates for drug delivery. Published by Elsevier B.V.
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