Journal
JOURNAL OF CONTROLLED RELEASE
Volume 163, Issue 3, Pages 322-334Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jconrel.2012.09.006
Keywords
Paclitaxel; Liposome; Drug targeting; Drug delivery systems; Anti-cancer drugs
Funding
- Grant Agency of the Czech Republic [GAP304/10/1951, GAP503/12/G147]
- Grant Agency of the Academy of Sciences of the Czech Republic [KAN200100801]
- Ministry of Agriculture of the Czech Republic [MZE0002716202]
- Ministry of Education, Youth and Sports of the Czech Republic [CZ.1.07/2.3.00/20.0164]
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Over the past three decades, taxanes represent one of the most important new classes of drugs approved in oncology. Paclitaxel (PTX), the prototype of this class, is an anti-cancer drug approved for the treatment of breast and ovarian cancer. However, notwithstanding a suitable premedication, present-day chemotherapy employing a commercial preparation of PTX (Taxol (R)) is associated with serious side effects and hypersensitivity reactions. Liposomes represent advanced and versatile delivery systems for drugs. Generally, both in vivomice tumor models and human clinical trials demonstrated that liposomal PTX formulations significantly increase a maximum tolerated dose (MTD) of PTX which outperform that for Taxol (R). Liposomal PTX formulations are in various stages of clinical trials. LEP-ETU (NeoPharm) and EndoTAG (R)-1 (Medigene) have reached the phase II of the clinical trials; Lipusu (R) (Luye Pharma Group) has already been commercialized. Present achievements in the preparation of various liposomal formulations of PTX, the development of targeted liposomal PTX systems and the progress in clinical testing of liposomal PTX are discussed in this review summarizing about 30 years of liposomal PTX development. (C) 2012 Elsevier B.V. All rights reserved.
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